A comparative study of some staining properties of crystals in a lympho-plasmocytoid cell, of Russell bodies in plasmocytes, and of amyloids--with special emphasis on their isoelectric points.

Bg ARTHUR F. GOLDBERG AND HELEN WENDLER DEANE T HIS STUDY was made to characterize intracellular crystals found in unusual lympho-plasmocytoid cells, which have been described elsewhere’ and for convenience will be termed crystal cells. For comparison, an examination was made of the related inclusions in plasmocytes ( Russell bodies ) , and also of primary, secondary, and senile cardiac amyloids. Their relative isoelectric points were determined by a staining method that effectively titrates the ionizable radicals of the compounds. Tile results suggest strongly that the crystals and Russell bodies are gamma globulins, whereas the amyloids studied resemble alpha glycoproteins. Two preliminary reports have been made.2”